Ashley combines X-ray crystallography and biophysics with molecular simulation to study the structure, folding and dynamics of proteins, with a particular focus on the design and engineering of proteins for medical and biotechnological application. His team is a unique and exciting mix of experimentalists and computational biologists using modelling and simulation to make predictions that can be tested in the lab.
Ashley Buckle's Articles
Life is a battle against disorder
There is no life without enzymes. But how did the evolution of these complex molecules get going more than three billion years ago? We describe a new mechanism that may help to understand how order is created from disorder, and the starting points for protein evolution.